Core Research Area

• Cell & Cell-free Therapy

Principal Investigators:

1. Dr. Raghavendra Upadhya, Assistant Professor

2. Dr. Samatha Bhat, Assistant Professor

Develop cell therapy and cell free therapy (secretome & extracellular vesicles) for various tissue repair and regeneration. Develop nanovesicle technology driven target delivery of therapeutic molecules for various tissue repair and regeneration. Identification of the molecular markers (micro-RNA and protein coding genes) related to stemness and understanding their role in determining the stem cell fate, their mechanism and signaling pathways contributing to stemness in cervical cancer

• Molecular Signal Transduction

Principal Investigator: Dr. Souvik Dey, Assistant Professor - Senior Scale

Reversible, non-hormonal male contraceptive development and endeavour for a better understanding of the biochemistry of the gamete functions in mammalian systems, with special emphasis on the interrelation between GSK3 (glycogen synthase kinase 3) and FTO (RNA-specific demethylases) in the regulation of mammalian spermatogenesis and fertility.

Development of gene editing-based approaches to target GSK3, isoform-selectively, to mitigate cancer phenotypes in human acute lymphoblastic leukemia (ALL) cell lines and clinical samples.

For more details, please visit the Lab website: http://deyresearchlab.in

• Biomaterials & 3D bioprinting

Principal Investigator: Dr. S V Kirthanashri, Associate Professor and In-charge Head

We are synthesizing biocompatible hybrid biomaterials that will be suitable for various tissue regeneration and develop scaffolds via 3D bioprinting for drug screening and tissue regeneration.

• Brain Aging & Neurotherapeutics 

Principal Investigator: Dr. Abhishek Kumar Singh, Associate Professor

Development of anti-aging strategies targeting autophagy pathways against brain aging and age-related neurodegenerative disorders 

Development and validation of a 3D model of brain aging in the dish as an alternative for animal uses for screening  discovery of novel anti-aging  molecules

Development and validation of nano-formulation using a cocktail of caloric restriction mimetics and biopolymeric materials for aging-induced  impaired neurogenesis and cognitive decline 

• Reproductive Therapeutics

Principal Investigator: Dr. Ramya Nair M T, Assistant Professor

The research focuses on several key areas within reproductive therapeutics. Firstly, it aims to elucidate the role of stem cells in addressing disorders related to the ovaries and endometrium, with the ultimate goal of developing innovative stem cell-based therapies for reproductive disorders. Additionally, there is an emphasis on the creation of a three-dimensional (3D) disease model for polycystic ovary syndrome (PCOS) and endometriosis, which will facilitate in vitro drug testing and advance our understanding of these complex conditions.  This integrated approach seeks to enhance therapeutic strategies and improve patient outcomes in reproductive health.

• Cancer Immunology and Immunotherapy

Principal Investigator: Dr. Subhashis Sarkar, Associate Professor

Our research lab focuses on advancing cancer immunotherapy through two strategic pillars: (a) the development of gene-edited allogeneic CAR-NK cell therapies and (b) the design of novel bispecific antibodies. By leveraging CRISPR-Cas9, we precisely engineer NK cells to enhance anti-tumor potency and persistence. Central to this effort is the use of non-viral gene delivery systems to optimize safety and manufacturing scalability. Concurrently, we develop bispecific antibodies to dual-target malignant cells and immune checkpoints. Integrating these engineering approached we aim to develop potent, "off-the-shelf" therapeutic solutions which will provide more accessible and effective treatment options across a broad range of oncology indications.

• Nanotechnology, Targeted Delivery Systems and Cancer Therapy

Principal Investigator: Dr. Ritu Kudarha, Assistant Professor

Our research focuses on nanotechnology‑based drug delivery and material science approaches for targeted cancer therapy. We work extensively on the design and engineering of polymeric, lipidic, and metal based nanoparticulate delivery systems for controlled, site‑specific administration of therapeutic and diagnostic agents. Our interests include nanoparticle synthesis and surface modification, with emphasis on targeted delivery platforms and cancer theranostics. The research integrates physicochemical characterization, in‑vitro biological evaluation, and translational strategies to develop multifunctional nanocarriers with enhanced therapeutic efficacy, diagnostic capability, and clinical relevance.